刘振花-开元游戏大厅app官网入口

 

刘振花

职称：副教授

联系电话：0371-23880680

e-mail：10200113@vip.henu.edu.cn

刘振花，博士，副教授，硕士生导师。

一、学习与工作经历：

1. 2011年获河南大学学士学位。

2. 2014年获中国科学院昆明植物研究所硕士学位。

3. 2017年获中国科学院昆明植物研究所博士学位。

4. 2017年至2023年5月，河南大学，药学院，讲师。

5. 2023年5月-至今，河南大学，农学院，讲师。

二．主要的研究方向：

（1）天然产物活性成分研究：以活性为导向的天然产物分离、结构鉴定，涉及“谱效关系-敲出技术-高分辨质谱技术”快速发现复杂中药体系中的活性成分。

（2）药理活性研究：活性成分的抗糖尿病、凝血、抗炎、免疫等活性的研究。

三、主持的重要研究项目：

1. 主持国家自然科学基金青年基金：黄花败酱改善3t3-l1脂肪细胞胰岛素抵抗的活性成分及作用机制研究（31900292），2020.01-2022.12

2. 主持河南省科技发展计划项目：环烯醚萜类化合物改善胰岛素抵抗作用及机制研究（202102110149），2019.12-2021.12

3. 主持河南省科技发展计划项目：黄花败酱降血糖功能研究（192102110112），2019.01-2020.12

4. 主持开封市科技局项目：药食两用资源黄花败酱降血糖活性成分及作用机制研究（1908005），2018.07-2020.07

5. 参加国家重点研发食用菌资源开发和高效加工关键技术研究：食用菌资源开发和高效加工关键技术研究（2018yfd0400202），2019.01-2021.12

6. 参加国家自然科学基金面上项目：基于质谱分子网络从近缘亚属发现重楼药材可替代资源的评价研究（31770391），2018.01-2021.12

7. 参加河南省科技发展计划项目：金针菇功能食品的研发（182102110092），2018.01-2019.12

四、代表性研究论文(*为通讯作者)：

1. meng-jun shi, yi-ping cui, cun-yu liu, chang-qin li, zhen-hua liu*, wen-yi kang*. cyps-mediated drug-drug interactions on psoralidin, isobavachalcone, neobavaisoflavone and daidzein in rats liver microsomes. food and chemical toxicology, 2020, 136 (2020): 111027-111035. sci top 2区

2. zhenhua liu, lanting xu, xiaoqing xu, yun niu, fatmas.a. saadeldeen,wenyi kang∗.effects and mechanisms of iridoid glycosides from patrinia scabiosaefolia on improving insulin resistance in 3t3-l1 adipocytes. food and chemical toxicology, 2019, 134, 110806. sci top 2区

3. wen-jing li, yan zhang, shu-jin shi, gen yang, zhen-hua liu*, jin-mei wang*, wen-yi kang*. spectrum-effect relationship of antioxidant and tyrosinase activity with malus pumila flowers by uplc-ms/ms and component knock-out method. food and chemical toxicology, 2019, doi, 10.1016/j.fct.2019.110754. sci top 2区

4. ying-ying niu, jing-dong, hui-min jiang, jin-mei wang, zhen-hua liu*, chang- yang ma, wen-yi kang*. effects of polysaccharide from malus halliana koehne flowers in cyclophosphamide-induced immunosuppression and oxidative stress on mice. oxidative medicine and cellular longevity. 2020, doi.org/10.1155/2020/1603735. sci 2区

5. chang-qin li, yi-ping cui, jie lu, cun-yu liu, si-tan chen, chang-yang ma, zhen-hua liu*, jin-mei wang*, wen-yi kang*. ionic liquid-based ultrasonic-assisted extraction coupled with hplc and artificial neural network analysis for ganoderma lucidum. molecules, 2020, 25, doi:10.3390/molecules25061309. sci 3区

6. zhen-hua liu, lan-ting xu, mei-mei xing, jin-feng wei, jin-mei wang, wen-yi kang. trelagliptin succinate: dpp-4 inhibitor to improve insulin resistance in adipocytes. biomedicine & pharmacotherapy, 2020, 125（2020）109952. sci 3区

7. xu-qiang liu, jing-dong, qiong-xin liang, hui-min david wang, zhen-hua liu*, rui-an xu* wen-yi kang*. coagulant effectsand mechanism of schefflera heptaphylla (l.) frodin. molecules, 2019, 24, 24,4547-4559. sci 3区

8. meng-jun shi, juan-juan zhang, cun-yu liu, yi-ping cui, chang-qin, li, zhen-hua liu*, wen-yi kang*. ionic liquid-based ultrasonic-assisted extraction to analyze seven compounds in psoralea fructus coupled with hplc. molecules, 2019, 24(9), 1699-1713. sci 3区

9. xiao-qing xu, fatma s. a. saadeldeen, lan-ting xu, ying-ying zhao, jin-feng wei, hui-min david wang*, zhen-hua liu*, wen-yi kang*. the mechanism of phillyrin from the leaves of forsythia suspensa for improving insulin resistance. biomed research international, 2019, doi, 10.1155/2019/3176483. sci 3区

10. li-li cui, mi-yun hu, peng-ran cao, yun niu, chang-qin li, zhen-hua liu*, wen-yi kang*. chemical constituents and coagulation activity of syringa oblata lindl flowers. bmc chemistry, 2019, doi, 10.1186/s13065-019-0621-8. sci 3区

11. li-li cui, xing-zi hou, wen-jing li, yu-chun leng, yang zhang, xin-juan li, zhen-hua liu*, wen-yi kang*. dynamic changes of secondary metabolites and tyrosinase activity of malus pumila flowers. bmc chemistry, 2019, doi, 10.1186/s13065-019-0602-y. sci 3区

12. zhen-hua liu, bo hou, liu yang, rui-jing ma, jin-yu li, jiang-miao hu*, jun zhou*. iridoids and bis-iridoids from patrinia scabiosaefolia. rsc advances, 2017, 7: 24940-24949. sci 3区

13. zhen-hua liu, rui-jing ma, liu yang, jin-yu li, jiang-miao hu, jun zhou. triterpenoids and iridoids from patrinia scabiosaefolia. fitoterapia, 2017, 119: 130-135. sci 3区

14. zhen-hua liu, huan yan, yong-ai si, wei ni, yu chen, li he, hai-yang liu*. bioactive spirostane glycosides from tacca plantaginea. steroids, 2016, 106: 86-92. sci 3区

15. zhen-hua liu, huan yan, yong-ai si, wei ni, yu chen, chang-xiang chen, lihe, zhong-quan zhang, hai-yang liu*. plantagiolides k–n, three new withanolides and one withanolideglucoside from tacca plantaginea. fitoterapia. 2015, 105: 210-214. sci 3区

16. peng-yu, wang, jian li, fatma alzahra k. attia, wen-yi kang, jin-feng wei, zhen-hua liu*, chang-qin li*. a critical review on chemical constituents and pharmacological effects of lilium. food science and human wellness, 2019, 8:330-336. sci 4区

17. zhen-hua liu, huan yan, hai-yang liu*. chemical constituents and bioactivities of plants of taccaceae. chemistry & biodiversity. 2015, 12: 221-237. sci 4区

五．奖励：

1. 康文艺，尹震花，王金梅，马常阳，张伟，姬利强，刘振花，张娟娟，李昌勤，魏金凤，李山雷，“谱效关系”结合“敲除技术”快速确定功效成分及功能产品开发，中国商业联合会科学技术奖，一等奖，2019